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Chemical Structure : Apixaban
CAS No.: 503612-47-3
Catalog No.: PC-45832Not For Human Use, Lab Use Only.
Apixaban (BMS-562247) is a highly potent, selective, efficacious, and orally bioavailable inhibitor of factor Xa (FXa) with Ki of 0.08 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 100 mg | $128 | In stock | |
| 200 mg | $198 | In stock | |
| 1 g | Get quote |
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Apixaban (BMS-562247) is a highly potent, selective, efficacious, and orally bioavailable inhibitor of factor Xa (FXa) with Ki of 0.08 nM.
Apixaban (BMS-562247) shows no affinity for thrombin (Ki>3 uM), does not alter human and rabbit platelet aggregation to ADP, gamma-thrombin, and collagen at 10 uM.
Apixaban (BMS-562247) produces dose-dependent antithrombotic effects with EC50 of 270 nM, 110 nM and 70 nM, respective in the AVST, venous thrombosis (VT) and ECAT rabbit models.
| M.Wt | 459.4971 | |
| Formula | C25H25N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 14.25 mg/mL; H2O：< 0.1 mg/mL |
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| Chemical Name/SMILES |
1H-Pyrazolo[3,4-c]pyridine-3-carboxamide, 4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]- |
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1. Pinto DJ, et al. J Med Chem. 2007 Nov 1;50(22):5339-56.
2. Wong PC, et al. J Thromb Haemost. 2008 May;6(5):820-9.
3. Wong PC, et al. J Thromb Haemost. 2008 Oct;6(10):1736-41.
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