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Chemical Structure : Apogossypol
Catalog No.: PC-43514Not For Human Use, Lab Use Only.
Apogossypol (NSC 736630) is a Bcl-2 family antagonist that binds to Bcl-XL, Bcl-2 and Bcl-xL with IC50 of 2.6, 2.8 and 3.69 uM, respectively.
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Apogossypol (NSC 736630) is a Bcl-2 family antagonist that binds to Bcl-XL, Bcl-2 and Bcl-xL with IC50 of 2.6, 2.8 and 3.69 uM, respectively.
Apogossypol induces apoptosis of tumor cell lines, inhibits the growth and proliferation of prostate cancer cells by downregulating Bcl‑2 protein expression and activating caspase‑3 and ‑8.
Apogossypol displays superior activity to gossypol in terms of reducing splenomegaly and reducing B-cell counts in spleens of Bcl-2-transgenic mice.
| M.Wt | 462.53 | |
| Formula | C28H30O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Becattini B, et al. Chem Biol. 2004 Mar;11(3):389-95.
2. Wei J, et al. Mol Cancer Ther. 2009 Apr;8(4):904-13.
3. Kitada S, et al. Blood. 2008 Mar 15;111(6):3211-9.
4. Zhan W, et al. Mol Med Rep. 2015 Jun;11(6):4142-8.
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