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Chemical Structure : Apomine
Catalog No.: PC-49778Not For Human Use, Lab Use Only.
Apomine (SR-45023A) is an oral biphosphonate antineoplastic compound inhibiting HMG-CoA reductase, induces HMG-CoA reductase degradation with EC50 of 0.88 uM.
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Apomine (SR-45023A) is an oral biphosphonate antineoplastic compound inhibiting HMG-CoA reductase, induces HMG-CoA reductase degradation with EC50 of 0.88 uM.
Apomine (SR-45023A) inhibited growth of a wide variety of tumor cell line with IC50 of 5-14 uM.
Apomine (SR-45023A) triggered apoptosis in HL60 cells in less than 2 h, induced caspase-3 activity at concentrations similar to their IC(50) values for cell proliferation.
Apomine (SR-45023A) selectively inhibits cell proliferation and induces tumor cell apoptosis through the farnesoid X receptor.
| M.Wt | 562.66 | |
| Formula | C28H52O7P2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Flach J, et al. Biochem Biophys Res Commun. 2000 Apr 2;270(1):240-6.
2. Alberts DS, et al. Clin Cancer Res. 2001 May;7(5):1246-50.
3. Toyota Y, et al. Bioorg Med Chem. 2020 Jul 15;28(14):115576.
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