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Chemical Structure : Apremilast
CAS No.: 608141-41-9
Catalog No.: PC-42891Not For Human Use, Lab Use Only.
Apremilast (CC-10004) is a potent, orally active PDE4 inhibitor with IC50 of 74 nM, inhibits TNF-α production in LPS-stimulated hPBMCs with IC50 of 77 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $128 | In stock | |
| 50 mg | $188 | In stock | |
| 100 mg | $298 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Apremilast (CC-10004) is a potent, orally active PDE4 inhibitor with IC50 of 74 nM, inhibits TNF-α production in LPS-stimulated hPBMCs with IC50 of 77 nM.
Apremilast (CC-10004) inhibits PBMC production of the chemokines CXCL9 and CXCL10, IFN-gamma and TNF-alpha, and IL-2, IL-12 and IL-23, also inhibits TNF-α by NK cells and keratinocytes.
Apremilast (CC-10004) significantly reduces epidermal thickness and proliferation, decreases the general histopathological appearance of psoriasiform features and reduces expression of TNF-α, human leukocyte antigen-DR and intercellular adhesion molecule-1 in the lesioned skin in model of psoriasis.
| M.Wt | 460.5002 | |
| Formula | C22H24N2O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Acetamide, N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]- |
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1. Man HW, et al. J Med Chem. 2009 Mar 26;52(6):1522-4.
2. McCann FE, et al. Arthritis Res Ther. 2010;12(3):R107.
3. Schafer PH, et al. Br J Pharmacol. 2010 Feb;159(4):842-55.
4. Gordon JN, et al. J Crohns Colitis. 2009 Sep;3(3):175-82.
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