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Chemical Structure : Aprocitentan
CAS No.: 1103522-45-7
Catalog No.: PC-60030Not For Human Use, Lab Use Only.
Aprocitentan (ACT132577) is the major and pharmacologically active metabolite of Macitentan, an orally active, dual endothelin receptor antagonist with IC50s of 3.4 nM and 987 nM for ETA/ETB receptor respectively, inhibits ET-1 and ET-2-induced contractions in functional assays.
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|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $498 | In stock | |
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Aprocitentan (ACT132577) is the major and pharmacologically active metabolite of Macitentan, an orally active, dual endothelin receptor antagonist with IC50s of 3.4 nM and 987 nM for ETA/ETB receptor respectively, inhibits ET-1 and ET-2-induced contractions in functional assays.
| M.Wt | 546.194 | |
| Formula | C16H14Br2N6O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-[5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl]sulfuric diamide |
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1. Iglarz M, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):736-45.
2. Kummer O, et al. Eur J Pharm Sci. 2009 Nov 5;38(4):384-8.
3. Sidharta PN, et al. Eur J Clin Pharmacol. 2011 Oct;67(10):977-84.
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