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Chemical Structure : Asapiprant
CAS No.: 932372-01-5
Catalog No.: PC-22638Not For Human Use, Lab Use Only.
Asapiprant (S-555739) is a potent and selective prostaglandin DP1 receptor antagonist with Ki of 0.44 nM, >300-fold selective over EP2 and other prostanoid receptors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $288 | In stock | |
| 10 mg | $438 | In stock | |
| 25 mg | $728 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Asapiprant (S-555739) is a potent and selective prostaglandin DP1 receptor antagonist with Ki of 0.44 nM, >300-fold selective over EP2 and other prostanoid receptors.
Asapiprant (S-555739) strongly inhibits the cAMP elevation elicited by PGD2 in human platelets with IC50 of 16 nM, 50-fold than another DP1 antagonist, S-5751 (840 nM).
Asapiprant (S-555739) inhibits cAMP elevation induced by PGD2 in guinea pigs, rats, and sheep with IC50 of 61, 74, and 15, respectively.
Asapiprant (S-555739) (3, 5 mg/kg) inhibits PGD2-induced nasal resistance (sRaw) in guinea pigs.
Asapiprant (S-555739) suppresses antigen-induced asthmatic responses, airway hyper-responsiveness, and cell infiltration and mucin production in lung.
| M.Wt | 501.55 | |
| Formula | C24H27N3O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
[2-(Oxazol-2-yl)-5-(4-{4-[(propan-2-yl)oxy]phenylsulfonyl}piperazine-1-yl)phenoxy] acetic acid |
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1. Takahashi G, et al. Eur J Pharmacol. 2015 Oct 15;765:15-23.
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