Catalog No.: PC-22638Not For Human Use, Lab Use Only.
Asapiprant (S-555739) is a potent and selective prostaglandin DP1 receptor antagonist with Ki of 0.44 nM, >300-fold selective over EP2 and other prostanoid receptors.
Asapiprant (S-555739) is a potent and selective prostaglandin DP1 receptor antagonist with Ki of 0.44 nM, >300-fold selective over EP2 and other prostanoid receptors. Asapiprant (S-555739) strongly inhibits the cAMP elevation elicited by PGD2 in human platelets with IC50 of 16 nM, 50-fold than another DP1 antagonist, S-5751 (840 nM). Asapiprant (S-555739) inhibits cAMP elevation induced by PGD2 in guinea pigs, rats, and sheep with IC50 of 61, 74, and 15, respectively. Asapiprant (S-555739) (3, 5 mg/kg) inhibits PGD2-induced nasal resistance (sRaw) in guinea pigs. Asapiprant (S-555739) suppresses antigen-induced asthmatic responses, airway hyper-responsiveness, and cell infiltration and mucin production in lung.
