Chemical Structure : Asenapine maleate
CAS No.:
85650-56-2
Asenapine maleate
(Org 5222 maleate;Org-5222 maleate;Org5222 maleate)
Catalog No. : PC-42808Not For Human Use, Lab Use Only.
Asenapine maleate (Org 5222) is a potent psychopharmacologic agent that shows high affinity for 5-HT, dopamine, histamine and adrenoceptors.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4280801
Biological Activity
Asenapine maleate (Org 5222) is a potent psychopharmacologic agent that shows high affinity for 5-HT, dopamine, histamine and adrenoceptors; shows much lower affinity (pKi<5) for muscarinic receptor; behaves as a potent antagonist 5-HT receptors (5-HT2A pKB=9.0), dopaime and adrenoceptors; shows strong antipsychotic potential in vivo.
Schizophrenia
Approved
Physicochemical Properties
M.Wt
401.8402
Formula
C21H20ClNO5
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1H-Dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-, (3aR,12bR)-rel-, (2Z)-2-butenedioate (1:1)
References
1. Room P, et al. Eur J Pharmacol. 1991 Dec 3;205(3):233-40.
2. Broekkamp CL, et al. Arzneimittelforschung. 1990 May;40(5):544-9.
3. Psychopharmacology (Berl). 2008 Feb;196(3):417-29.
4. Shahid M, et al. J Psychopharmacol. 2009 Jan;23(1):65-73.
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