Astemizole | H1 receptor antagonist, hERG blocker

Chemical Structure : Astemizole

CAS No.: 68844-77-9

Astemizole (R43512, R 43512)

Catalog No.: PC-28213Not For Human Use, Lab Use Only.

Astemizole (R43512) is a second-generation histamine H1-receptor antagonist with IC50 of 4 nM, also shows potent hERG K+ channel blocking activity with IC50 of 0.9 nM.

Packing	Price	Stock
25 mg	$58	In stock
50 mg	$88	In stock
100 mg	$128	In stock
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Biological Activity

Astemizole (R43512) is a second-generation histamine H1-receptor antagonist with IC50 of 4 nM, also shows potent hERG K+ channel blocking activity with IC50 of 0.9 nM.

Physicochemical Properties

M.Wt	458.58
Formula	C28H31FN4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-Fluorobenzyl)-N-(1-(4-methoxyphenethyl)piperidin-4-yl)-1H-benzo[d]imidazol-2-amine

References

1. Nicholson AN, et al. Br J Clin Pharmacol. 1982 Nov;14(5):683-90.

2. Laduron PM, et al. Mol Pharmacol. 1982 Mar;21(2):294-300.

3. Suessbrich H, et al. FEBS Lett. 1996 Apr 29;385(1-2):77-80.

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Astemizole (R43512, R 43512)

Biological Activity

Physicochemical Properties

References

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