Asundexian | FXIa inhibitor | Probechem Biochemicals

Chemical Structure : Asundexian

CAS No.: 2064121-65-7

Asundexian (BAY 2433334, BAY2433334)

Catalog No.: PC-73137Not For Human Use, Lab Use Only.

Asundexian (BAY 2433334) is a highly potent, selective and orally active inhibitor of Factor XIa (FXIa) with IC50 of 0.92 nM.

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Biological Activity

Asundexian (BAY 2433334) is a highly potent, selective and orally active inhibitor of Factor XIa (FXIa) with IC50 of 0.92 nM.

Asundexian (BAY 2433334) shows favorable selectivity of greater than 1000-fold versus serine proteases associated with the hemostatic system, including FVIIa, FIXa, FXa, FXIIa, thrombin, urokinase, tissue plasminogen activator, activated protein C.

Asundexian (BAY 2433334) prolongs the clotting time in the aPTT assay in human plasma with EC50 of 0.2 uM.

Asundexian (BAY 2433334) reduces FXIa activity, thrombin generation triggered by contact activation or low concentrations of tissue factor, and prolongs activated partial thromboplastin time in human, rabbit and various other species, but not in rodents.

Asundexian (BAY 2433334) reduces thrombus weight in the FeCl2 -injury models.

Asundexian (BAY 2433334) reduces thrombus weight when administered before or during thrombus formation in the AV-shunt model.

Physicochemical Properties

M.Wt	592.936
Formula	C26H21ClF4N6O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	100 mM in DMSO (59.3 mg/mL)
Chemical Name/SMILES	(S)-4-(2-(4-(5-chloro-2-(4-(trifluoromethyl)-1H-1,2,3-triazol-1-yl)phenyl)-5-methoxy-2-oxopyridin-1(2H)-yl)butanamido)-2-fluorobenzamide

References

1. Stefan Heitmeier, et al. J Thromb Haemost. 2022 Mar 15. doi: 10.1111/jth.15700.
2. Susanne Roehrig, et al. Journal of Medicinal Chemistry September 5, 2023.

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Asundexian (BAY 2433334, BAY2433334)

Biological Activity

Physicochemical Properties

References

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