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Chemical Structure : Ataciguat
CAS No.: 254877-67-3
Catalog No.: PC-61607Not For Human Use, Lab Use Only.
Ataciguat (HMR-1766) is a potent, specific soluble guanylate cyclase (sGC) activator with EC50 of 0.51 uM, preferentially activates the NO-insensitive heme-oxidized form of sGC.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $138 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | $548 | In stock | |
| 250 mg | Get quote |
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Ataciguat (HMR-1766) is a potent, specific soluble guanylate cyclase (sGC) activator with EC50 of 0.51 uM, preferentially activates the NO-insensitive heme-oxidized form of sGC.
Ataciguat (HMR-1766) increases cGMP levels in cultured rat aortic smooth muscle cells.
Ataciguat (HMR-1766) induces vasorelaxation of isolated endothelium-denuded rat aorta, porcine coronary arteries, and human corpus cavernosum with EC50 of 1-10 uM.
Ataciguat (HMR-1766) decreases arterial blood pressure in anesthetized pigs.
| M.Wt | 576.478 | |
| Formula | C21H19Cl2N3O6S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-chloro-2-[(5-chlorothiophen-2-yl)sulfonylamino]-N-(4-morpholin-4-ylsulfonylphenyl)benzamide |
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1. Schindler U, et al. Mol Pharmacol. 2006 Apr;69(4):1260-8.
2. Evgenov OV, et al. Nat Rev Drug Discov. 2006 Sep;5(9):755-68.
3. Schäfer A, et al. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2813-8.
4. Zhou Z, et al. Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1763-71.
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