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Chemical Structure : Ataciguat sodium
Catalog No.: PC-61608Not For Human Use, Lab Use Only.
Ataciguat (HMR-1766) is a potent, specific soluble guanylate cyclase (sGC) activator with EC50 of 0.51 uM, preferentially activates the NO-insensitive heme-oxidized form of sGC.
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Ataciguat (HMR-1766) is a potent, specific soluble guanylate cyclase (sGC) activator with EC50 of 0.51 uM, preferentially activates the NO-insensitive heme-oxidized form of sGC; increases cGMP levels in cultured rat aortic smooth muscle cells; induces vasorelaxation of isolated endothelium-denuded rat aorta, porcine coronary arteries, and human corpus cavernosum with EC50 of 1-10 uM; decreases arterial blood pressure in anesthetized pigs.
Heart Failure
Phase 2 Clinical
| M.Wt | 598.46 | |
| Formula | C21H18Cl2N3NaO6S3 | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Schindler U, et al. Mol Pharmacol. 2006 Apr;69(4):1260-8.
2. Evgenov OV, et al. Nat Rev Drug Discov. 2006 Sep;5(9):755-68.
3. Schäfer A, et al. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2813-8.
4. Zhou Z, et al. Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1763-71.
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