Chemical Structure : Ataciguat sodium
CAS No.:
254976-06-2
Ataciguat sodium
(HMR-1766;HMR1766)
Catalog No.: PC-61608Not For Human Use, Lab Use Only.
Ataciguat (HMR-1766) is a potent, specific soluble guanylate cyclase (sGC) activator with EC50 of 0.51 uM, preferentially activates the NO-insensitive heme-oxidized form of sGC.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Ataciguat (HMR-1766) is a potent, specific soluble guanylate cyclase (sGC) activator with EC50 of 0.51 uM, preferentially activates the NO-insensitive heme-oxidized form of sGC; increases cGMP levels in cultured rat aortic smooth muscle cells; induces vasorelaxation of isolated endothelium-denuded rat aorta, porcine coronary arteries, and human corpus cavernosum with EC50 of 1-10 uM; decreases arterial blood pressure in anesthetized pigs.
Heart Failure
Phase 2 Clinical
Physicochemical Properties
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M.Wt
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598.46
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Formula
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C21H18Cl2N3NaO6S3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-chloro-2-[(5-chlorothiophen-2-yl)sulfonylamino]-N-(4-morpholin-4-ylsulfonylphenyl)benzamide sodium salt
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References
1. Schindler U, et al. Mol Pharmacol. 2006 Apr;69(4):1260-8.
2. Evgenov OV, et al. Nat Rev Drug Discov. 2006 Sep;5(9):755-68.
3. Schäfer A, et al. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2813-8.
4. Zhou Z, et al. Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1763-71.
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