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Atazanavir sulfate

Chemical Structure : Atazanavir sulfate

CAS No.: 229975-97-7

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Atazanavir sulfate (BMS 232632 sulfate;BMS-232632 sulfate;BMS232632 sulfate)

Catalog No.: PC-45187Not For Human Use, Lab Use Only.

A highly potent HIV-1 protease inhibitor that exhibits potent anti-HIV activity EC50 of 2.6-5.3 nM and EC90 of 9-15 nM in cell culture.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A highly potent HIV-1 protease inhibitor that exhibits potent anti-HIV activity EC50 of 2.6-5.3 nM and EC90 of 9-15 nM in cell culture; shows synergistic antiviral effects in HIV-infected PBMCs; used to treat and prevent HIV/AIDS.

HIV Infection

Approved

Physicochemical Properties

M.Wt 802.934
Formula C38H54N6O11S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO; H2O: < 0.1 mg/mL
Chemical Name/SMILES

2,5,6,10,13-Pentaazatetradecanedioic acid, 3,12-bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-[[4-(2-pyridinyl)phenyl]methyl]-, 1,14-dimethyl ester, (3S,8S,9S,12S)-, sulfate

References

1. Robinson BS, et al. Antimicrob Agents Chemother. 2000 Aug;44(8):2093-9.

2. Gong YF, et al. Antimicrob Agents Chemother. 2000 Sep;44(9):2319-26.

3. Drusano GL, et al. J Infect Dis. 2001 Apr 1;183(7):1126-9.

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