Atibuclimab
(Anti-human CD14 mAb, human IgG4-Kappa; IC14)
Catalog No.: PC-Ab1060Not For Human Use, Lab Use Only.
Atibuclimab (IC14) is a chimeric CD14 antibody investigated for the treatment of patients with severe sepsis. Human monocyte differentiation antigen CD14 is a pattern recognition receptor (PRR) that enhances innate immune responses. Atibuclimab (IC14) attenuated the LPS-induced release of MIP-1beta, but not of MIP-1alpha. IL-8 and MCP-1, but not MIP-1alpha and MIP-1b, circulate in RBC-associated form during endotoxemia..
Atibuclimab (IC14) is a chimeric CD14 antibody investigated for the treatment of patients with severe sepsis. Human monocyte differentiation antigen CD14 is a pattern recognition receptor (PRR) that enhances innate immune responses. Atibuclimab (IC14) attenuated the LPS-induced release of MIP-1beta, but not of MIP-1alpha. IL-8 and MCP-1, but not MIP-1alpha and MIP-1b, circulate in RBC-associated form during endotoxemia.
Physicochemical Properties
M.Wt
Formula
Human IgG4-Kappa
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
PBS, pH 7.0
Contains no stabilizers or preservatives
