Atogepant | CGRP inhibitor | Probechem Biochemicals

Chemical Structure : Atogepant

CAS No.: 1374248-81-3

Atogepant (MK-8031, AGN-241689)

Catalog No.: PC-60031Not For Human Use, Lab Use Only.

Atogepant (MK-8031) is a potent and selective calcitonin gene-related peptide (CGRP) receptor antagonist with Ki of 2 pM (hCGRP).

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Biological Activity

Atogepant (MK-8031) is a potent and selective calcitonin gene-related peptide (CGRP) receptor antagonist with Ki of 2 pM (hCGRP).

Atogepant shows similar affinity for rhesus CGRP receptors (Ki = 0.009 nM), but a weaker affinity for rat and dog CGRP receptors (Ki = 0.7 nM and Ki = 1.2 nM, respectively).

Atogepant inhibited [125I]-amylin binding on membranes from cells expressing human recombinant AMY1 (Ki=1.8 nM).

Atogepant inhibited AMY-induced cAMP accumulation with an IC50 of 2.4 nM on the AMY1 receptor, and an IC50 of 1418 nM on the AMY3 receptor.

Atogepant exhibited significant affinity for the amylin1 receptor but lacked appreciable affinities for adrenomedullin, calcitonin and other known neurotransmitter receptor targets.

Atogepant dose-dependently inhibited facial allodynia in the rat nitroglycerine model and produced significant CIDV inhibition in primates.

Physicochemical Properties

M.Wt	603.525
Formula	C29H23F6N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3'S)-N-[(3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamide

References

1. Rubio-Beltran E, et al. Cephalalgia. 2020 Apr;40(4):357-366.

Atogepant (MK-8031, AGN-241689)

Biological Activity

Physicochemical Properties

References

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