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Atomoxetine

Chemical Structure : Atomoxetine

CAS No.: 83015-26-3

Atomoxetine ((R)-Tomoxetine, LY-139603)

Catalog No.: PC-63052Not For Human Use, Lab Use Only.

Atomoxetine ((R)-Tomoxetine, LY-139603) is a potent, selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM.

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Biological Activity

Atomoxetine ((R)-Tomoxetine, LY-139603) is a potent, selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM.
Atomoxetine shows weak affinity for 5-HT and dopamine transporters with IC50 of 77 and 1,451 nM, respectively.
Atomoxetine has been approved for the treatment of attention deficit hyperactivity disorder (ADHD).

Physicochemical Properties

M.Wt 255.361
Formula C17H21NO
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine

References

1. Bymaster FP, et al. Neuropsychopharmacology. 2002 Nov;27(5):699-711.

2. Sauer JM, et al. Clin Pharmacokinet. 2005;44(6):571-90.

3. Passamonti L, et al. Psychopharmacology (Berl). 2017 Aug;234(15):2289-2297.

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