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Atomoxetine hydrochloride

Chemical Structure : Atomoxetine hydrochloride

CAS No.: 82248-59-7

Atomoxetine hydrochloride (Tomoxetine, LY-139603)

Catalog No.: PC-63053Not For Human Use, Lab Use Only.

Atomoxetine hydrochloride((R)-Tomoxetine LY-139603) is a potent, selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM.

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Biological Activity

Atomoxetine hydrochloride((R)-Tomoxetine LY-139603) is a potent, selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM.
Atomoxetine shows weak affinity for 5-HT and dopamine transporters with IC50 of 77 and 1,451 nM, respectively.
Atomoxetine has been approved for the treatment of attention deficit hyperactivity disorder (ADHD).

Physicochemical Properties

M.Wt 291.819
Formula C17H22ClNO
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine hydrochloride

References

1. Bymaster FP, et al. Neuropsychopharmacology. 2002 Nov;27(5):699-711.

2. Sauer JM, et al. Clin Pharmacokinet. 2005;44(6):571-90.

3. Passamonti L, et al. Psychopharmacology (Berl). 2017 Aug;234(15):2289-2297.

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