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Chemical Structure : Atrasentan
CAS No.: 173937-91-2
Catalog No.: PC-21324Not For Human Use, Lab Use Only.
Atrasentan (ABT-627, A-147627) is a potent, selective and orally active nonpeptide endothelin A-receptor (ETA) with IC50 of 0.055 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote |
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Atrasentan (ABT-627, A-147627) is a potent, selective and orally active nonpeptide endothelin A receptor (ETA) with IC50 of 0.055 nM.
Atrasentan (ABT-627, A-147627) significantly inhibits LNCaP and C4-2b prostate cancer cell growth.
Atrasentan (ABT-627, A-147627) inhibits ET-1 radioligand binding with IC50 of 0.36 nM, 1000-fold selectivity for the ET(A) vs the ET(B) receptor.
Atrasentan (ABT-627, A-147627) also is a potent inhibitor (IC50=0.16 nM) of phosphoinositol hydrolysis stimulated by ET-1, and it antagonizes the ET-1-induced contraction of the rabbit aorta with a pA(2)=9.20.
| M.Wt | 510.63 | |
| Formula | C29H38N2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2r,3r,4s)-4-(benzo[d][1,3]dioxol-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)pyrrolidine-3-carboxylicacid |
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1. Winn M, et al. J Med Chem. 1996 Mar 1;39(5):1039-48.
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