Aureobasidin A (AbA, Basifungin) is a cyclic depsipetide antifungal antibiotic, inhibits the inositolphosphorylceramide synthase AUR1. Aureobasidin A (AbA) arrests growth of yeast cells through both ceramide intoxication and deprivation of essential inositolphosphorylceramides. Aureobasidin A (AbA) is highly active in vitro against many pathogenic fungi, including Candida albicans, Cryptococcus neoformans, Blastomyces dermatitidis and Histoplasma capsulatum. Aureobasidin A (AbA) is highly tolerated by mice and showed good efficacy in the treatment of murine systemic candidiasis when given orally or subcutaneously.
Physicochemical Properties
M.Wt
1101.42
Formula
C60H92N8O11
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Month
Shipping
Solubility
Chemical Name/SMILES
References
1. Kino K, et al. FEBS Lett. 1996 Dec 9;399(1-2):29-32.
2. Hashida-Okado T, et al. Mol Gen Genet. 1996 May 23;251(2):236-44.
3. Takesako K, et al. J Antibiot (Tokyo). 1993 Sep;46(9):1414-20.
4. Heidler SA, et al. Antimicrob Agents Chemother. 1995 Dec;39(12):2765-9.
