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Chemical Structure : Avanbulin
CAS No.: 798577-91-0
Catalog No.: PC-36086Not For Human Use, Lab Use Only.
Avanbulin (BAL27862, BAL-27862) is a novel microtubule-destabilizing agent that potently inhibits tubulin assembly at 37°C with IC50 of 1.4 uM in tubulin-binding assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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Avanbulin (BAL27862, BAL-27862) is a novel microtubule-destabilizing agent that potently inhibits tubulin assembly at 37°C with IC50 of 1.4 uM in tubulin-binding assays.
Avanbulin (BAL27862) potently binds to unassembled tubulin with a stoichiometry of 1 mol/mol tubulin and a dissociation constant of 244±30 nM, BAL27862 bound to tubulin independently of vinblastine, without the formation of tubulin oligomers.
Avanbulin (BAL27862) inhibits tumor cell proliferation through activation of the spindle assembly checkpoint, inhibits EB1-dependent migration and invasion and promotes differentiation of glioblastoma stem-like cells both in vitro and in vivo.
| M.Wt | 387.403 | |
| Formula | C20H17N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-[(4-{1-[2-(4-aminophenyl)-2-oxoethyl]-1H-benzimidazol-2-yl}-1,2,5-oxadiazol-3-yl)amino]propanenitrile |
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1. Prota AE, et al. J Mol Biol. 2014 Apr 17;426(8):1848-60.
2. Kolb EA, et al. Pediatr Blood Cancer. 2015 Jun;62(6):1106-9.
3. Bergès R, et al. Mol Cancer Ther. 2016 Nov;15(11):2740-2749.
4. Dudka D, et al. Nat Commun. 2018 May 23;9(1):2042.
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