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Axl-IN-21

Chemical Structure : Axl-IN-21

CAS No.: 2086274-31-7

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Axl-IN-21

Catalog No.: PC-62809Not For Human Use, Lab Use Only.

Axl-IN-21 is a selective and potent inhibitor of wild-type Axl with IC50 of 2.2 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Axl-IN-21 is a selective and potent inhibitor of wild-type Axl with IC50 of 2.2 nM; shows high selectivity in a 56 kinase panel, no CYP inhibition across the CYP isoforms; shows good permeability in PAMPA assay, and demonstrates good oral exposure in rat PK studies (F=38%, CL=53 (mg/kg/min)); a useful molecule for further in vivo target validation studies to support the role of Axl in cancer.

Physicochemical Properties

M.Wt 518.607
Formula C22H26N6O5S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-N-(2-(4-(4-(methylsulfonyl)morpholin-2-yl)thiazol-2-yl)-4-morpholinophenyl)-1H-imidazole-2-carboxamide

References

1. Keung W, et al. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1099-1104.

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