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Chemical Structure : Axl-IN-21
Catalog No.: PC-62809Not For Human Use, Lab Use Only.
Axl-IN-21 is a selective and potent inhibitor of wild-type Axl with IC50 of 2.2 nM.
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Axl-IN-21 is a selective and potent inhibitor of wild-type Axl with IC50 of 2.2 nM; shows high selectivity in a 56 kinase panel, no CYP inhibition across the CYP isoforms; shows good permeability in PAMPA assay, and demonstrates good oral exposure in rat PK studies (F=38%, CL=53 (mg/kg/min)); a useful molecule for further in vivo target validation studies to support the role of Axl in cancer.
| M.Wt | 518.607 | |
| Formula | C22H26N6O5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Keung W, et al. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1099-1104.
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