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Azeloprazole

Chemical Structure : Azeloprazole

CAS No.: 955095-45-1

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Azeloprazole (E-3710, Z-215)

Catalog No.: PC-60032Not For Human Use, Lab Use Only.

Azeloprazole (E-3710, Z-215) is a potent proton pump inhibitor that irreversibly inhibits H+,K+-ATPase activity with IC50 of 0.28 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Azeloprazole (E-3710, Z-215) is a potent proton pump inhibitor that irreversibly inhibits H+,K+-ATPase activity with IC50 of 0.28 uM.
    Azeloprazole inhibits histamine-stimulated gastric acid secretion with ED50 of 0.18-0.2 mg/kg in gastric fistula model in dogs, displays 2.3-fold more potency over Esomeprazole.

    Physicochemical Properties

    M.Wt 429.535
    Formula C22H27N3O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-2-(((4-((2,2-Dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole

    References

    1. Kodama K, et al. J Pharmacol Exp Ther. 2010 Aug;334(2):395-401.

    2. Toda R, et al. J Clin Pharmacol. 2017 Nov 28. doi: 10.1002/jcph.1038.

    3. Toda R, et al. Xenobiotica. 2017 Nov 2:1-15. doi: 10.1080/00498254.2017.1390625.

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