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Azeloprazole sodium

Chemical Structure : Azeloprazole sodium

CAS No.: 955095-47-3

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Azeloprazole sodium (E-3710;Z-215)

Catalog No.: PC-60077Not For Human Use, Lab Use Only.

A novel potent, orally active proton pump inhibitor that irreversibly inhibits H+,K+-ATPase activity with IC50 of 0.28 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A novel potent, orally active proton pump inhibitor that irreversibly inhibits H+,K+-ATPase activity with IC50 of 0.28 uM; inhibits histamine-stimulated gastric acid secretion with ED50 of 0.18-0.2 mg/kg in gastric fistula model in dogs, displays 2.3-fold more potency over Esomeprazole.

Other Indication

Phase 1 Clinical

Physicochemical Properties

M.Wt 452.525
Formula C22H27N3NaO4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-2-(((4-((2,2-Dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole, sodium salt

References

1. Kodama K, et al. J Pharmacol Exp Ther. 2010 Aug;334(2):395-401.

2. Toda R, et al. J Clin Pharmacol. 2017 Nov 28. doi: 10.1002/jcph.1038.

3. Toda R, et al. Xenobiotica. 2017 Nov 2:1-15. doi: 10.1080/00498254.2017.1390625.

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