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Chemical Structure : Azimilide
CAS No.: 149908-53-2
Catalog No.: PC-45471Not For Human Use, Lab Use Only.
Azimilide (NE-10064) is a class ΙΙΙ antiarrhythmic agent that blocks hERG channel, blocks HERG channel at 0.1 and 1 Hz with IC50s of 1.4 uM and 5.2 uM respectively.
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|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
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Azimilide (NE-10064) is a class ΙΙΙ antiarrhythmic agent that blocks hERG channel, blocks HERG channel at 0.1 and 1 Hz with IC50s of 1.4 uM and 5.2 uM respectively.
Azimilide blocks the rapidly activating component of the delayed rectifier, IKr (IC50=0.4 uM), and inhibits IKs (IC50=3 uM); shows anti-arrhythmic effects.
| M.Wt | 457.9531 | |
| Formula | C23H28ClN5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2,4-Imidazolidinedione, 1-[[[5-(4-chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]- |
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1. Busch AE, et al. Br J Pharmacol. 1998 Jan;123(1):23-30.
2. Fermini B, et al. J Cardiovasc Pharmacol. 1995 Aug;26(2):259-71.
3. Walker BD, et al. Cardiovasc Res. 2000 Oct;48(1):44-58.
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