Chemical Structure : Azimilide dihydrochloride
CAS No.: 149888-94-8
Catalog No.: PC-45472Not For Human Use, Lab Use Only.
Azimilide dihydrochloride is a class ΙΙΙ antiarrhythmic agent that blocks hERG channel; blocks HERG channel at 0.1 and 1 Hz with IC50s of 1.4 uM and 5.2 uM respectively.
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	Azimilide dihydrochloride is a class ΙΙΙ antiarrhythmic agent that blocks hERG channel; blocks HERG channel at 0.1 and 1 Hz with IC50s of 1.4 uM and 5.2 uM respectively.
	Azimilide blocks the rapidly activating component of the delayed rectifier, IKr (IC50=0.4 uM), and inhibits IKs (IC50=3 uM); shows anti-arrhythmic effects.
| M.Wt | 530.875 | |
| Formula | C23H30Cl3N5O3 | |
| Appearance | Solid | |
| Storage | 
                            
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| Solubility | 
                             DMSO: < 10.4 mg/mL  | 
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| Chemical Name/SMILES | 
                             2,4-Imidazolidinedione, 1-[[[5-(4-chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-, hydrochloride (1:2)  | 
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1. Busch AE, et al. Br J Pharmacol. 1998 Jan;123(1):23-30.
2. Fermini B, et al. J Cardiovasc Pharmacol. 1995 Aug;26(2):259-71.
3. Walker BD, et al. Cardiovasc Res. 2000 Oct;48(1):44-58.

                
                
                
                
                
                
                
                
            
            
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