Azvudine | HCV NS5B inhibitor | Probechem Biochemicals

Chemical Structure : Azvudine

CAS No.: 1011529-10-4

Azvudine (RO 0622)

Catalog No.: PC-63018Not For Human Use, Lab Use Only.

Azvudine (RO 0622) is a potent HCV NS5B RNA polymerase inhibitor, inhibits HCV replication in the replicon system with IC50 of 24 nM.

Packing	Price	Stock
5 mg	$138	In stock
10 mg	$218	In stock
25 mg	$378	In stock
50 mg	$588	In stock
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Biological Activity

Azvudine (RO 0622) is a potent HCV NS5B RNA polymerase inhibitor, inhibits HCV replication in the replicon system with IC50 of 24 nM.
Azvudine inhibits RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or containing S96T or S282T point mutations (IC50=10-100 nM).

Physicochemical Properties

M.Wt	286.223
Formula	C9H11FN6O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-amino-1-[(2R,3S,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

References

1. Klumpp K, et al. J Biol Chem. 2008 Jan 25;283(4):2167-75.

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Azvudine (RO 0622)

Biological Activity

Physicochemical Properties

References

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