Catalog No.: PC-27193Not For Human Use, Lab Use Only.
B0AT1 inhibitor compound 3 is a potent, selective, allosteric inhibitor of neutral amino acid transporter B0AT1 (SLC6A19) with IC50 of 513 nM and 295 nM for human and mouse B0AT1 respectively.
B0AT1 inhibitor compound 3 is a potent, selective, allosteric inhibitor of neutral amino acid transporter B0AT1 (SLC6A19) with IC50 of 513 nM and 295 nM for human and mouse B0AT1 respectively.
B0AT1 inhibitor compound 3 shows high binding affinity with Kd of 47.0 nM in cell membrane-binding assays using human B0AT1-ACE2 co-expressing cells.
B0AT1 inhibitor compound 3 preferentially binds to the Na⁺-bound conformation of B0AT1.
B0AT1 inhibitor compound 3 treatment (30 mg/kg, oral) significantly increased urinary phenylalanine (Phe) excretion in phenylketonuria (PKU) model mice.
