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Chemical Structure : BA6b9
Catalog No.: PC-22989Not For Human Use, Lab Use Only.
BA6b9 is a small molecule, allosteric SK4 channel blocker, reversibly inhibits the SK4 currents with IC50 of 8.6 uM, targets Ca2+-calmodulin (CaM)-PIP2-binding domain.
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BA6b9 is a small molecule, allosteric SK4 channel blocker, reversibly inhibits the SK4 currents with IC50 of 8.6 uM, targets Ca2+-calmodulin (CaM)-PIP2-binding domain.
BA6b9 inhibits SK4 channels by interacting with two specific residues, Arg191 and His192 in the linker S4-S5, not conserved in SK1–SK3 subunits.
cytosol-facing CaM–PIP2-binding domain (CPBD).
BA6b9 (10 uM) potently inhibits the SK4 currents by 66%.
BA6b9 significantly prolonged atrial and atrioventricular effective refractory periods on the electrophysiological properties of the isolated rat hearts.
| M.Wt | 233.31 | |
| Formula | C14H19NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Burg S, et al. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2202926119.
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