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Chemical Structure : BAM7
CAS No.: 331244-89-4
Catalog No.: PC-22106Not For Human Use, Lab Use Only.
BAM7 is a selective Bax activator,, competes with FITC-BIM SAHB for BAX binding with IC50 of 3.3 uM, activates BAX and BAX-dependent cell death.
BAM7 is selective for the BH3-binding site on BAX.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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BAM7 is a selective Bax activator,, competes with FITC-BIM SAHB for BAX binding with IC50 of 3.3 uM, activates BAX and BAX-dependent cell death.
BAM7 is selective for the BH3-binding site on BAX.
BAM7 triggers in vitro BAX oligomerization, BAX-mediated pore formation and BAX-dependent cell death.
BAM7 induces the biochemical and morphologic features of BAX-mediated apoptosis in Bak−/− MEFs.
BAM7 directly binds the BAX trigger site and initiates the characteristic structural changes that lead to functional BAX activation in vitro.
| M.Wt | ||
| Formula | ||
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-Methyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione 4-[2-(2-ethoxyphenyl)hydrazone] |
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1. Daniele S, et al. ACS Chem Neurosci. 2018 Jan 17;9(1):85-99.
2. Gavathiotis E, et al. Nat Chem Biol. 2012 Jul;8(7):639-45.
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