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BAN ORL 24

Chemical Structure : BAN ORL 24

CAS No.: 1401463-54-4

BAN ORL 24 (BAN-ORL-24;BAN ORL-24)

Catalog No.: PC-43402Not For Human Use, Lab Use Only.

BAN ORL 24 is a potent, selective, non-peptide nociceptin/orphanin FQ receptor (NOP receptor, ORL1) antagonist with IC50 of 0.27 nM, displays no significant activity for κ-, μ- and δ-receptors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BAN ORL 24 is a potent, selective, non-peptide nociceptin/orphanin FQ receptor (NOP receptor, ORL1) antagonist with IC50 of 0.27 nM, displays no significant activity for κ-, μ- and δ-receptors.
BAN ORL 24 produces a concentration-dependent displacement of [(3)H]N/OFQ binding to CHO(hNOP) cell membranes with pKi of 9.62 and selectivity (1000 fold) over classical opioid receptors.
BAN ORL 24 antagonizes the pronociceptive and antinociceptive effects of N/OFQ in vivo.

Physicochemical Properties

M.Wt 506.5076
Formula C27H37Cl2N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-Pyrrolidinecarboxamide, 1-(phenylmethyl)-N-(3-spiro[isobenzofuran-1(3H),4'-piperidin]-1'-ylpropyl)-, (2R)-

References

1. Fischetti C, et al. Eur J Pharmacol. 2009 Jul 1;614(1-3):50-7.

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