Catalog No.: PC-42345Not For Human Use, Lab Use Only.
BAR501 is a potent, selective GPBAR1 (GPCR19, TGR5) agonist devoid of any FXR agonistic activity, effectively transactivates GPBAR1 in HEK293 cells with EC50 of 1 uM.
BAR501 is a potent, selective GPBAR1 (GPCR19, TGR5) agonist devoid of any FXR agonistic activity, effectively transactivates GPBAR1 in HEK293 cells with EC50 of 1 uM.
BAR501 effectively reduces hepatic perfusion pressure and counteracts the vasoconstriction activity of norepinephrine in rats, effectively protects against development of endothelial dysfunction by increasing liver CSE expression and activity and by reducing endothelin (ET)-1 gene expression in CCl4 models.
Physicochemical Properties
M.Wt
406.64164
Formula
C26H46O3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: 10 mM
Chemical Name/SMILES
Cholane-3,7,24-triol, 6-ethyl-, (3α,5β,6β,7β)-
References
1. Renga B, et al. PLoS One. 2015 Nov 5;10(11):e0141082.
2. Biagioli M, et al. J Immunol. 2017 Jul 15;199(2):718-733.
3. Carino A, et al. Sci Rep. 2017 Oct 20;7(1):13689.
