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Chemical Structure : BAU-243
Catalog No.: PC-20689Not For Human Use, Lab Use Only.
BAU-243 (BAU243) is a novel BH3 mimetic Bcl-2 inhibitor with a high affinity, effectively reduces overall GBM cell proliferation including a subpopulation of cancer-initiating cells.
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BAU-243 (BAU243) is a novel BH3 mimetic Bcl-2 inhibitor with a high affinity, effectively reduces overall GBM cell proliferation including a subpopulation of cancer-initiating cells.
BAU-243 reduces survival of GBM cells and tumor-initiating stem cells (A172 cells, IC50=18.2 uM).
BAU-243 induces limited apoptosis and cell cycle arrest in low Bcl-2 expressing cells.
BAU-243 does not induce apoptosis in high Bcl-2 expressing SHSY-5Y cells despite the significant anti-proliferative effect.
BAU-243 promotes autophagic cell death through the disruption of Beclin 1 and Bcl-2 interaction, regardless of Bcl-2 expression level.
BAU-243 (25 mg/kg) reduced tumor growth in vivo with lower dose compared to other BH3 mimetics (ABT-263, 75 mg/kg).
BAU-243 demonstrated a remarkable anti-proliferative effect on the cancer sub-population that is considered a true representative of tumor-initiating GBM stem-like cells.
BAU-243 interacts with critical residues of Bcl-2 that plays role in the binding of Beclin 1 BH3 domain, showing that it can hinder Beclin 1:Bcl-2 complex formation, freeing Beclin 1 to activate the autophagy pathway.
| M.Wt | 501.60 | |
| Formula | C28H27N3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Calis S, et al. Cell Death Discov. 2022 Oct 29;8(1):433.
2. Tutumlu G, et al. Front Chem. 2020;8.
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