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BAY-298

Chemical Structure : BAY-298

CAS No.: 2471978-97-7

BAY-298 (BAY298)

Catalog No.: PC-72913Not For Human Use, Lab Use Only.

BAY-298 (BAY298) is a highly potent, selective luteinizing hormone receptor (LH-R) inhibitor with IC50 of 96 nM and 23 nM for hLH-R and rLH-R, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BAY-298 (BAY298) is a highly potent, selective luteinizing hormone receptor (LH-R) inhibitor with IC50 of 96 nM and 23 nM for hLH-R and rLH-R, respectively.
BAY-899 suppressed hLH-induced ovarian marker gene expression in cetrorelix-treated female rats.
BAY-899 counteracted the hLH-induced increase in plasma testosterone levels in male rats, and reduced serum estradiol levels in female rats

Physicochemical Properties

M.Wt 473.932
Formula C27H21ClFN3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(5S)-5-(4-Chlorophenyl)-N-[4-(4-fluorophenoxy)phenyl]-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxamide

References

1. Lars Wortmann, et al. J Med Chem. 2019 Nov 27;62(22):10321-10341.

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