Chemical Structure : BAY-6092
CAS No.:
2413109-18-7
BAY-6092
(BAY6092)
Catalog No.: PC-22052Not For Human Use, Lab Use Only.
BAY-6092 (BAY6092) is a potent, selective YAP1/TAZ pathway inhibitor with IC50 of 1.6 nM in TEAD-luciferase assays, directly tareget PGGT1B, a subunit of the geranylgeranyltransferase-I (GGTase-I) complex.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BAY-6092 (BAY6092) is a potent, selective YAP1/TAZ pathway inhibitor with IC50 of 1.6 nM in TEAD-luciferase assays, directly tareget PGGT1B, a subunit of the geranylgeranyltransferase-I (GGTase-I) complex.
BAY-6092 potently inhibits human GGTase-I activity with biochemical IC50 of 64 nM.
BAY-6092 potently inhibits MDA-MB-231 and HT-1080 proliferation with IC50 of 49 and 9 nM respectively.
BAY-6092 effectively promoted YAP1 inactivation by translocation to the cytoplasm.
BAY-6092 dose-dependently down-regulates YAP1/TAZ target genes ANKRD1, CTGF, CYR61, CDC6, and DKK1.
BAY-6092 effectively inhibits GGTase-I substrates of the Rho-GTPase family in MDA-MB-231 cells, and causes YAP1/TAZ inactivation.
BAY-6092 impairs cancer cell proliferation and invasion in vitro with IC50 of <1 uM against a panel of cell lines from different tumor types.
Physicochemical Properties
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M.Wt
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490.52
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Formula
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C26H29F3N2O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-5-(2-methoxyphenyl)-9-((R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl)-3,9-diazaspiro[5.5]undecan-2-one
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References
1. Graham K, et al. Cell Chem Biol. 2024 Mar 19:S2451-9456(24)00087-4.
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