Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : BAY-6092
Catalog No.: PC-22052Not For Human Use, Lab Use Only.
BAY-6092 (BAY6092) is a potent, selective YAP1/TAZ pathway inhibitor with IC50 of 1.6 nM in TEAD-luciferase assays, directly tareget PGGT1B, a subunit of the geranylgeranyltransferase-I (GGTase-I) complex.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
BAY-6092 (BAY6092) is a potent, selective YAP1/TAZ pathway inhibitor with IC50 of 1.6 nM in TEAD-luciferase assays, directly tareget PGGT1B, a subunit of the geranylgeranyltransferase-I (GGTase-I) complex.
BAY-6092 potently inhibits human GGTase-I activity with biochemical IC50 of 64 nM.
BAY-6092 potently inhibits MDA-MB-231 and HT-1080 proliferation with IC50 of 49 and 9 nM respectively.
BAY-6092 effectively promoted YAP1 inactivation by translocation to the cytoplasm.
BAY-6092 dose-dependently down-regulates YAP1/TAZ target genes ANKRD1, CTGF, CYR61, CDC6, and DKK1.
BAY-6092 effectively inhibits GGTase-I substrates of the Rho-GTPase family in MDA-MB-231 cells, and causes YAP1/TAZ inactivation.
BAY-6092 impairs cancer cell proliferation and invasion in vitro with IC50 of <1 uM against a panel of cell lines from different tumor types.
| M.Wt | 490.52 | |
| Formula | C26H29F3N2O4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Graham K, et al. Cell Chem Biol. 2024 Mar 19:S2451-9456(24)00087-4.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
