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BAY-7081

Chemical Structure : BAY-7081

CAS No.: 3036022-06-4

BAY-7081 (BAY7801)

Catalog No.: PC-49572Not For Human Use, Lab Use Only.

BAY-7801 (BAY7801) is a potent, selective, and orally bioavailable PDE9A inhibitor with IC50 of 15 nM (human PDE9A), 49-fold selectivity over PDE1.

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    Biological Activity

    BAY-7801 (BAY7801) is a potent, selective, and orally bioavailable PDE9A inhibitor with IC50 of 15 nM (human PDE9A), 49-fold selectivity over PDE1.
    BAY-7801 also potently inhibits mouse and rat PDE9A with IC50 of 34 and 42 nM, respectively.
    BAY-7801 displays >100-fold selectivity over other phosphodiesterases.
    BAY-7801 showed an EC50 of 1 μM which favorably compares to 1.7 μM for PF-04447943 in cell-based assays.
    BAY-7801 (10 mg/kg, 5 weeks) significantly reduced hypertrophy of the left atrium and improved the heart function in transverse aortic constriction mouse model.

    Physicochemical Properties

    M.Wt 362.902
    Formula C19H27ClN4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    ent-4-(6-Azaspiro[2.5]octan-6-yl)-2-oxo-8-propyl-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-3-carbonitrile Hydrochloride

    References

    1. Daniel Meibom, et al. J Med Chem. 2022 Dec 22;65(24):16420-16431.

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