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BAY-747

Chemical Structure : BAY-747

CAS No.: 1609342-18-8

BAY-747 (BAY 1165747, BAY747)

Catalog No.: PC-72945Not For Human Use, Lab Use Only.

BAY-747 (BAY 1165747, BAY747) is a novel potent, selective, brain-penetrant soluble guanylate cyclase (sGC) stimulator with MEC value of 0.06 uM for stimulation of cGMP formation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BAY-747 (BAY 1165747, BAY747) is a novel potent, selective, brain-penetrant soluble guanylate cyclase (sGC) stimulator with MEC value of 0.06 uM for stimulation of cGMP formation.
    Oral administration of BAY-747 to male Wistar rats enhanced memory acquisition in the object location task (OLT), reversed L-NAME induced memory impairments in the OLT.
    BAY-747 enhanced hippocampal GluA1-containing AMPA receptor (AMPAR) trafficking in a chemical LTP model for memory acquisition using acute mouse hippocampal slices in ex vivo.

    Physicochemical Properties

    M.Wt 416.473
    Formula C22H26F2N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO (4.2 mg/mL)

    Chemical Name/SMILES

    N-[(2S)-2-Amino-2-methylbutyl]-8-[(2,6-difluorophenyl)methoxy]-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxamide

    References

    1. Nelissen E, et al. Sci Rep. 2022 Mar 4;12(1):3589.
    2. Vakalopoulos A, et al. J Med Chem. 2023 Apr 11. doi: 10.1021/acs.jmedchem.2c02082.

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