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You are here:Home-Chemical Inhibitors & Agonists-GPCR-Luteinizing Hormone Receptor (LHR)-BAY-899
BAY-899

Chemical Structure : BAY-899

CAS No.: 2471967-92-5

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BAY-899 (BAY899)

Catalog No.: PC-72912Not For Human Use, Lab Use Only.

BAY-899 (BAY899) is a highly potent, selective luteinizing hormone receptor (LH-R) inhibitor with IC50 of 185 nM and 46 nM for hLH-R and rLH-R, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BAY-899 (BAY899) is a highly potent, selective luteinizing hormone receptor (LH-R) inhibitor with IC50 of 185 nM and 46 nM for hLH-R and rLH-R, respectively.
BAY-899 reduces sex hormone levels in vivo.
BAY-899 is a valuable tool compound to study hLH-R signaling in vitro and to interfere with the production of sex hormones in vivo.

Physicochemical Properties

M.Wt 459.457
Formula C25H19F2N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(5S)-N-[2-(4-Fluorophenoxy)pyrimidin-5-yl]-5-(4-fluorophenyl)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxamide

References

1. Lars Wortmann, et al. J Med Chem. 2019 Nov 27;62(22):10321-10341.

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