Catalog No.: PC-42493Not For Human Use, Lab Use Only.
BAY 11-7085 is an inhibitor of the expression of ICAM-1, VCAM-1, and E-selectin in human endothelial cells (IC50=5-10 uM), acts by selectively inhibiting TNFα-induced phosphorylation of IκB-α without affecting the constitutive IκB-α phosphorylation.
BAY 11-7085 is an inhibitor of the expression of ICAM-1, VCAM-1, and E-selectin in human endothelial cells (IC50=5-10 uM), acts by selectively inhibiting TNFα-induced phosphorylation of IκB-α without affecting the constitutive IκB-α phosphorylation.
BAY 11-7085 prevents PMA-induced NF-kappaB nuclear translocation.
BAY 11-7085 reduces swelling in both the rat carrageenan paw edema assay and in a rat adjuvant arthritis model.
