Chemical Structure : BAY 2413555
CAS No.:
2206665-50-9
BAY 2413555
(BAY2413555, BAY-2413555)
Catalog No.: PC-23358Not For Human Use, Lab Use Only.
BAY 2413555 is a potent, selective positive allosteric modulator of M2 muscarinic acetylcholine receptor (M2 mAChR, M2R) with EC50 of 2.0 nM in functional M2-GIRK assays.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BAY 2413555 is a potent, selective positive allosteric modulator of M2 muscarinic acetylcholine receptor (M2 mAChR, M2R) with EC50 of 2.0 nM in functional M2-GIRK assays.
BAY 2413555 is a potent positive allosteric modulator with high cooperativity with the endogenous agonist acetylcholine and negligible agonistic activity.
BAY 2413555 shows no significant allosteric effects on other human muscarinic acetylcholine receptors, and has no any agonistic activity on any of the M1-M5 receptors.
BAY 2413555 shows binding Kd of 17 nM for the human M2R in radioligand binding assay.
BAY 2413555 reduced the heart rate in a dose-dependent manner on the heart rate of isolated rat hearts, in the presence of the M2 agonist carbachol.
Physicochemical Properties
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M.Wt
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584.40
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Formula
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C23H17F9N4O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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7-((3R,4R)-3,4-dihydroxypyrrolidin-1-yl)-6-fluoro-4-oxo-N-((S)-3,3,4,4,4-pentafluorobutan-2-yl)-1-(2,4,6-trifluorophenyl)-1,4-dihydro-1,8-naphthyridine-3-carboxamide
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References
1. Vakalopoulos A, et al. J Med Chem. 2024 Oct 28. doi: 10.1021/acs.jmedchem.4c01590.
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