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Chemical Structure : BAY 41-2272
CAS No.: 256376-24-6
Catalog No.: PC-43008Not For Human Use, Lab Use Only.
BAY 41-2272 is a potent, NO-independent, orally available soluble guanylate cyclase (sGC) stimulator with IC50 of 0.3 uM (relaxation of preconstricted aortic rings).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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BAY 41-2272 is a potent, NO-independent, orally available soluble guanylate cyclase (sGC) stimulator with IC50 of 0.3 uM (relaxation of preconstricted aortic rings).
BAY 41-2272 targets the cysteine 238 and cysteine 243 region in the alpha1-subunit of sGC, sensitizes sGC to its physiological stimulator nitric oxide.
BAY 41-2272 potently unloads the heart, increases cardiac output, and preserves glomerular filtration rate without activation of the renin-angiotensin-aldosterone system in experimental congestive heart failure models.
| M.Wt | 360.3876 | |
| Formula | C20H17FN6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 17.5 mg/mL |
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| Chemical Name/SMILES |
4-Pyrimidinamine, 5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]- |
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1. Baracat JS, et al. Eur J Pharmacol. 2003 Sep 12;477(2):163-9.
2. Boerrigter G, et al. Circulation. 2003 Feb 11;107(5):686-9.
3. Stasch JP, et al. Nature. 2001 Mar 8;410(6825):212-5.
4. Straub A, et al. Bioorg Med Chem Lett. 2001 Mar 26;11(6):781-4.
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