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BAY 41-8543

Chemical Structure : BAY 41-8543

CAS No.: 256498-66-5

BAY 41-8543 (BAY418543, BAY41-8543)

Catalog No.: PC-63048Not For Human Use, Lab Use Only.

BAY 41-8543 is an NO-independent sGC (soluble guanylyl cyclase) stimulator, inhibits collagen-mediated aggregation in washed human platelets (IC50=90 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BAY 41-8543 is an NO-independent sGC (soluble guanylyl cyclase) stimulator, inhibits collagen-mediated aggregation in washed human platelets (IC50=90 nM).
BAY 418543 is a potent direct stimulator of the cyclic GMP/PKG/VASP pathway in platelets and synergizes with NO over a wide range of concentrations.

Physicochemical Properties

M.Wt 420.452
Formula C21H21FN8O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-4,6-pyrimidinediamine

References

1. Stasch JP, et al. Br J Pharmacol. 2002 Jan;135(2):333-43.

2. Stasch JP, et al. Br J Pharmacol. 2002 Jan;135(2):344-55.

3. Amirjanians M, et al. Oncotarget. 2017 May 2;8(18):29613-29624.

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