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Chemical Structure : BAY 41-8543
CAS No.: 256498-66-5
Catalog No.: PC-63048Not For Human Use, Lab Use Only.
BAY 41-8543 is an NO-independent sGC (soluble guanylyl cyclase) stimulator, inhibits collagen-mediated aggregation in washed human platelets (IC50=90 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $348 | In stock | |
| 50 mg | $548 | In stock | |
| 100 mg | Get quote |
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BAY 41-8543 is an NO-independent sGC (soluble guanylyl cyclase) stimulator, inhibits collagen-mediated aggregation in washed human platelets (IC50=90 nM).
BAY 418543 is a potent direct stimulator of the cyclic GMP/PKG/VASP pathway in platelets and synergizes with NO over a wide range of concentrations.
| M.Wt | 420.452 | |
| Formula | C21H21FN8O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-4,6-pyrimidinediamine |
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1. Stasch JP, et al. Br J Pharmacol. 2002 Jan;135(2):333-43.
2. Stasch JP, et al. Br J Pharmacol. 2002 Jan;135(2):344-55.
3. Amirjanians M, et al. Oncotarget. 2017 May 2;8(18):29613-29624.
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