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Chemical Structure : BAY 60-2770
CAS No.: 1027642-43-8
Catalog No.: PC-63047Not For Human Use, Lab Use Only.
BAY 60-2770 is an NO-independent activator of sGC (soluble guanylyl cyclase) with EC50 of 5.4 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $348 | In stock | |
| 50 mg | $558 | In stock | |
| 100 mg | Get quote |
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BAY 60-2770 is an NO-independent activator of sGC (soluble guanylyl cyclase) with EC50 of 5.4 nM.
BAY 60-2770 demonstrates vasodilator activity in the pulmonary and systemic vascular beds that is enhanced by ODQ and NOS inhibition.
| M.Wt | 623.645 | |
| Formula | C35H33F4NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-({(4-Carboxybutyl)[2-(5-fluoro-2-{[4'-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]amino}methyl)benzoic acid |
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1. Pankey EA, et al. Am J Physiol Heart Circ Physiol. 2011 Mar;300(3):H792-802.
2. Knorr A, et al. Arzneimittelforschung. 2008;58(2):71-80.
3. Jones AW, et al. J Pharmacol Exp Ther. 2010 Oct;335(1):85-91.
4. Mendes-Silverio CB, et al. PLoS One. 2012;7(11):e47223.
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