Chemical Structure : BAY 60-7550
CAS No.:
439083-90-6
BAY 60-7550
(Bay60-7550)
Catalog No.: PC-22039Not For Human Use, Lab Use Only.
BAY 60-7550 (Bay60-7550) is a potent and selective PDE2 inhibitor with Ki of 3.8 nM, IC50 of 4.7 nM (human PDE2A), and 2.0 nM (bovine purified PDE2).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BAY 60-7550 (Bay60-7550) is a potent and selective PDE2 inhibitor with Ki of 3.8 nM, IC50 of 4.7 nM (human PDE2A), and 2.0 nM (bovine purified PDE2).
BAY 60-7550 displays 50-fold selectivity over PDE1, and 100-800-fold over other PDEs.
BAY 60-7550 enhances long-term potentiation of synaptic transmission without altering basal synaptic transmission in cultured neurons and hippocampal slices.
BAY 60-7550 improves the performance of rats in social and object recognition memory tasks, and reversed MK801-induced deficits in spontaneous alternation in mice in a T-maze.
Physicochemical Properties
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M.Wt
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476.58
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Formula
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C27H32N4O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(3,4-dimethoxybenzyl)-7-{(1R)-1-[(1R)-1-hydroxyethyl]-4-phenylbutyl}-5-methyl imidazo[5,1-f][1,2,4]triazin-4(3H)-one
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References
1. Boess FG, et al. Neuropharmacology. 2004 Dec;47(7):1081-92.
2. Castro LR, et al. Circulation. 2006 May 9;113(18):2221-8.
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