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BAY 60-7550

Chemical Structure : BAY 60-7550

CAS No.: 439083-90-6

BAY 60-7550 (Bay60-7550)

Catalog No.: PC-22039Not For Human Use, Lab Use Only.

BAY 60-7550 (Bay60-7550) is a potent and selective PDE2 inhibitor with Ki of 3.8 nM, IC50 of 4.7 nM (human PDE2A), and 2.0 nM (bovine purified PDE2).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BAY 60-7550 (Bay60-7550) is a potent and selective PDE2 inhibitor with Ki of 3.8 nM, IC50 of 4.7 nM (human PDE2A), and 2.0 nM (bovine purified PDE2).
BAY 60-7550 displays 50-fold selectivity over PDE1, and 100-800-fold over other PDEs.
BAY 60-7550 enhances long-term potentiation of synaptic transmission without altering basal synaptic transmission in cultured neurons and hippocampal slices.
BAY 60-7550 improves the performance of rats in social and object recognition memory tasks, and reversed MK801-induced deficits in spontaneous alternation in mice in a T-maze.

Physicochemical Properties

M.Wt 476.58
Formula C27H32N4O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(3,4-dimethoxybenzyl)-7-{(1R)-1-[(1R)-1-hydroxyethyl]-4-phenylbutyl}-5-methyl imidazo[5,1-f][1,2,4]triazin-4(3H)-one

References

1. Boess FG, et al. Neuropharmacology. 2004 Dec;47(7):1081-92.

2. Castro LR, et al. Circulation. 2006 May 9;113(18):2221-8.

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