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Chemical Structure : BAY 73-6691
Catalog No.: PC-61334Not For Human Use, Lab Use Only.
BAY 73-6691 is a potent and selective PDE9 inhibitor with IC50 of 55 nM and 100 nM for human and murine PDE9, respectively.
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BAY 73-6691 is a potent and selective PDE9 inhibitor with IC50 of 55 nM and 100 nM for human and murine PDE9, respectively.
BAY 73-6691 shows only moderate activity against other cyclic nucleotide-specific PDEs.
BAY 73-6691 induces concentration-dependent intracellular cGMP accumulation combined with sGC activator BAY 58-2667 or BAY 41-2272.
BAY 73-6691 attenuates the scoplamine-induced retention deficit and the MK-801-induced short-term memory deficits, improves learning and memory in rodents.
| M.Wt | 356.73 | |
| Formula | C15H12ClF3N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wunder F, et al. Mol Pharmacol. 2005 Dec;68(6):1775-81.
2. van der Staay FJ, et al. Neuropharmacology. 2008 Oct;55(5):908-18.
3. Almeida CB, et al. Br J Haematol. 2008 Sep;142(5):836-44.
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