BAY 73-6691 is a potent and selective PDE9 inhibitor with IC50 of 55 nM and 100 nM for human and murine PDE9, respectively.
BAY 73-6691 shows only moderate activity against other cyclic nucleotide-specific PDEs.
BAY 73-6691 induces concentration-dependent intracellular cGMP accumulation combined with sGC activator BAY 58-2667 or BAY 41-2272.
BAY 73-6691 attenuates the scoplamine-induced retention deficit and the MK-801-induced short-term memory deficits, improves learning and memory in rodents.
