BB-Cl-Amidine

Chemical Structure : BB-Cl-Amidine

CAS No.: 1802637-39-3

Catalog No.: PC-20328Not For Human Use, Lab Use Only.

BB-Cl-Amidine a peptidylarginine deminase (PAD) inhibitor, irreversibly inactivates all four PAD subtypes (kinact/KI=16,100, 4,100, 6,800, and 13,300 M-1min-1 for PAD1-4, respectively).

Packing	Price	Stock
5 mg	$78	In stock
10 mg	$118	In stock
25 mg	$198	In stock
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Biological Activity

BB-Cl-Amidine is a peptidylarginine deminase (PAD) inhibitor, irreversibly inactivates all four PAD subtypes (kinact/KI=16,100, 4,100, 6,800, and 13,300 M-1min-1 for PAD1-4, respectively).

BB-Cl-Amidine also is a potent small-molecule inhibitor of STING targeting STING oligomerization.

BB-Cl-Amidine inhibits STING signaling and production of type I IFNs, IFN-stimulated genes (ISGs) and NFκB-dependent cytokines, but not other pattern recognition receptors.

BB-Cl-amidine alleviated pathology resulting from accrual of cytosolic DNA in Trex-1 mutant mice.

BB-Cl-Amidine inhibited STING oligomerization through modification of Cys148.

Physicochemical Properties

M.Wt	459.98
Formula	C26H26ClN5O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-[1,1'-biphenyl]-4-carboxamide

References

1. Humphries F, et al. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2305420120.

BB-Cl-Amidine

Biological Activity

Physicochemical Properties

References

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