You are here:Home-Chemical Inhibitors & Agonists-Metabolic Enzyme/Protease-Protein Arginine Deiminase (PAD)-BB-Cl-Amidine
BB-Cl-Amidine

Chemical Structure : BB-Cl-Amidine

CAS No.: 1802637-39-3

BB-Cl-Amidine

Catalog No.: PC-20328Not For Human Use, Lab Use Only.

BB-Cl-Amidine a peptidylarginine deminase (PAD) inhibitor, irreversibly inactivates all four PAD subtypes (kinact/KI=16,100, 4,100, 6,800, and 13,300 M-1min-1 for PAD1-4, respectively).

Packing Price Stock Quantity
5 mg $88 In stock
10 mg $128 In stock
25 mg $218 In stock
50 mg $358 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BB-Cl-Amidine is a peptidylarginine deminase (PAD) inhibitor, irreversibly inactivates all four PAD subtypes (kinact/KI=16,100, 4,100, 6,800, and 13,300 M-1min-1 for PAD1-4, respectively).
BB-Cl-Amidine also is a potent small-molecule inhibitor of STING targeting STING oligomerization.
BB-Cl-Amidine inhibits STING signaling and production of type I IFNs, IFN-stimulated genes (ISGs) and NFκB-dependent cytokines, but not other pattern recognition receptors.
BB-Cl-amidine alleviated pathology resulting from accrual of cytosolic DNA in Trex-1 mutant mice.
BB-Cl-Amidine inhibited STING oligomerization through modification of Cys148.

Physicochemical Properties

M.Wt 459.98
Formula C26H26ClN5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-[1,1'-biphenyl]-4-carboxamide

References

1. Humphries F, et al. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2305420120.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: