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BBT594

Chemical Structure : BBT594

CAS No.: 882405-89-2

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BBT594 (NVP-BBT594, BBT-594)

Catalog No.: PC-45558Not For Human Use, Lab Use Only.

BBT594 (NVP-BBT594) is a potent RET inhibitor that can impairs GDNF-RET signaling and GDNF-dependent growth of MCF7-LTED cells.

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5 mg $98 In stock
10 mg $148 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BBT594 (NVP-BBT594) is a potent RET inhibitor that can impairs GDNF-RET signaling and GDNF-dependent growth of MCF7-LTED cells.
BBT594 significantly enhances the antiproliferative effects of letrozole (SF50=2.9 nM).

Physicochemical Properties

M.Wt 569.5781
Formula C28H30F3N7O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: ≥ 33 mg/mL
Chemical Name/SMILES

1H-Indole-1-carboxamide, 5-[[6-(acetylamino)-4-pyrimidinyl]oxy]-2,3-dihydro-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-

References

1. Morandi A, et al. Cancer Res. 2013 Jun 15;73(12):3783-95.

2. Andreucci E, et al. Oncotarget. 2016 Dec 6;7(49):80543-80553.

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