Chemical Structure : BC-1293
CAS No.:
1219395-86-4
BC-1293
(BC1293)
Catalog No.: PC-22789Not For Human Use, Lab Use Only.
BC-1293 is a specific small molecule inhibitor of bacterial-induced ubiquitin E3 ligase subunit FBXO24, abrogates FBXO24-DARS2 binding, exhibits immunostimulatory properties.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BC-1293 is a specific small molecule inhibitor of bacterial-induced ubiquitin E3 ligase subunit FBXO24, abrogates FBXO24-DARS2 binding, exhibits immunostimulatory properties.
BC-1293 potentiated Pam3CSK4 induced secretion of both endogenous and ectopically expressed Flag-DARS2 from cells.
BC-1293 significantly increased secretion of IL-6, TNFα, and IL-1β from BEAS-2B, CD14 + , and THP-1 cells respectively, compared to vehicle or Pam3CSK4 alone.
BC-1293 also triggered release of TNFα and IL-1β from BEAS2-2B and CD14+ cells, respectively
BC-1293 (0, 1, 10 and 20 μM) displayed a significant stimulatory effect of BC-1293 on IL-6 secretion in Fbxo24-WT precision cut lung slice (PCLS) cultures, but not PCLS derived from Fbxo24+/- mice.
Physicochemical Properties
|
M.Wt
|
492.59
|
|
Formula
|
C26H28N4O4S
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
5-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-2-methyl-N-(1-oxo-1-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)propan-2-yl)benzenesulfonamide
|
References
1. Johnson BS, et al. Nat Commun. 2024 Jul 22;15(1):6172.
Contact Us
sales@probechem.com
