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Chemical Structure : BC-1293
Catalog No.: PC-22789Not For Human Use, Lab Use Only.
BC-1293 is a specific small molecule inhibitor of bacterial-induced ubiquitin E3 ligase subunit FBXO24, abrogates FBXO24-DARS2 binding, exhibits immunostimulatory properties.
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BC-1293 is a specific small molecule inhibitor of bacterial-induced ubiquitin E3 ligase subunit FBXO24, abrogates FBXO24-DARS2 binding, exhibits immunostimulatory properties.
BC-1293 potentiated Pam3CSK4 induced secretion of both endogenous and ectopically expressed Flag-DARS2 from cells.
BC-1293 significantly increased secretion of IL-6, TNFα, and IL-1β from BEAS-2B, CD14 + , and THP-1 cells respectively, compared to vehicle or Pam3CSK4 alone.
BC-1293 also triggered release of TNFα and IL-1β from BEAS2-2B and CD14+ cells, respectively
BC-1293 (0, 1, 10 and 20 μM) displayed a significant stimulatory effect of BC-1293 on IL-6 secretion in Fbxo24-WT precision cut lung slice (PCLS) cultures, but not PCLS derived from Fbxo24+/- mice.
| M.Wt | 492.59 | |
| Formula | C26H28N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Johnson BS, et al. Nat Commun. 2024 Jul 22;15(1):6172.
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