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Chemical Structure : BC54
Catalog No.: PC-61333Not For Human Use, Lab Use Only.
BC54 is a potent and biologically-active PDE4/7 inhibitor with IC50 of 50-100 nM for PDE4A/B/D, and 140 nM for both PDE7A/B.
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BC54 is a potent and biologically-active PDE4/7 inhibitor with IC50 of 50-100 nM for PDE4A/B/D, and 140 nM for both PDE7A/B.
BC54 showed only modest activity (IC50=3 uM) against PDE2A and PDE11A, and little to no activity (IC50 >10 uM) against PDE1C/3B/5A /8A/9A/10A.
BC54 displays exceptional anti-inflammatory activity and induces apoptosis in CLL cells.
| M.Wt | 408.458 | |
| Formula | C22H24N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. de Medeiros AS, et al. Cell Signal. 2017 Sep 1;40:73-80.
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