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Chemical Structure : BCL6-IN-8
Catalog No.: PC-62538Not For Human Use, Lab Use Only.
BCL6-IN-8 (BCL6-i) is a potent, irreversible and cell-active BCL6 inhibitor with inact/KI value of 1.9 × 104 M-1 s-1, targets Cys53 located at the protein-protein interaction interface.
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BCL6-IN-8 (BCL6-i) is a potent, irreversible and cell-active BCL6 inhibitor with inact/KI value of 1.9 × 104 M-1 s-1, targets Cys53 located at the protein-protein interaction interface.
BCL6-IN-8 shows intracellular PPI inhibitory activity between BCL6 and its corepressors, thus resulting in BCL6-dependent DLBCL cell growth inhibition.
BCL6-i is a cell-active chemical probe with the most potent BCL6 inhibitory activity reported to date.
| M.Wt | 666.553 | |
| Formula | C30H37Cl2N5O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sameshima T, et al. Biochemistry. 2018 Feb 7. doi: 10.1021/acs.biochem.7b00732.
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