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BCL6 PROTAC 15

Chemical Structure : BCL6 PROTAC 15

CAS No.: 2257479-54-0

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BCL6 PROTAC 15

Catalog No.: PC-35717Not For Human Use, Lab Use Only.

BCL6 PROTAC 15 is a novel B-cell lymphoma 6 (BCL6) PROTAC, significantly degrade BCL6 in a number of DLBCL cell lines, but neither BCL6 inhibition nor degradation selectively induces marked phenotypic response..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BCL6 PROTAC 15 is a novel B-cell lymphoma 6 (BCL6) PROTAC, significantly degrade BCL6 in a number of DLBCL cell lines, but neither BCL6 inhibition nor degradation selectively induces marked phenotypic response.

    Physicochemical Properties

    M.Wt 976.482
    Formula C47H58ClN9O12
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-((R)-25-chloro-41-methyl-42-oxo-41,42,43,44-tetrahydro-5,8-dioxa-3-aza-4(6,8)-quinolina-2(2,4)-pyrimidina-1(1,2)-piperazinacyclononaphane-14-yl)-N-(3-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)propyl)-4-oxobutanamide compound with ethane (1:1)

    References

    1. McCoull W, et al. ACS Chem Biol. 2018 Oct 17. doi: 10.1021/acschembio.8b00698.

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