TP-021 (BCL6 inhibitor 8c) |CAS:2130878-25-8 Probechem Biochemicals

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Chemical Structure : BCL6 inhibitor 8c

CAS No.: 2130878-25-8

BCL6 inhibitor 8c (TP-021, BCL6-IN-8c)

Catalog No.: PC-61016Not For Human Use, Lab Use Only.

TP-021 (BCL6 inhibitor 8c) is a potent, in vivo-active BCL6 inhibitor with IC50 of 0.1 uM in ELISA assays.

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5 mg	$198	In stock
10 mg	$298	In stock
25 mg	$498	In stock
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Biological Activity

TP-021 (BCL6 inhibitor 8c) is a potent, in vivo-active BCL6 inhibitor with IC50 of 0.1 uM in ELISA assays.
BCL6 inhibitor 8c exhibits good cellular BCL6BTB/ BCoR PPI inhibitory activity in the submicromolar range (M2H IC50=0.72 uM).
BCL6 inhibitor 8c showed a good pharmacokinetic profile, which is acceptable for both in vitro and in vivo studies.

Physicochemical Properties

M.Wt	417.846
Formula	C20H20ClN3O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-((2-Chloro-4-nitro-5-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)amino)-3,4-dihydroquinolin-2(1H)-one

References

1. Yasui T, et al. Bioorg Med Chem. 2017 Sep 1;25(17):4876-4886.

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BCL6 inhibitor 8c (TP-021, BCL6-IN-8c)

Biological Activity

Physicochemical Properties

References

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